Virtual screening and repurposing of FDA approved drugs against COVID-19 main protease.
Identifieur interne : 000077 ( Main/Exploration ); précédent : 000076; suivant : 000078Virtual screening and repurposing of FDA approved drugs against COVID-19 main protease.
Auteurs : Mahmoud Kandeel [Égypte] ; Mohammed Al-Nazawi [Arabie saoudite]Source :
- Life sciences [ 1879-0631 ] ; 2020.
Abstract
In December 2019, the Coronavirus disease-2019 (COVID-19) virus has emerged in Wuhan, China. In this research, the first resolved COVID-19 crystal structure (main protease) was targeted in a virtual screening study by of FDA approved drugs dataset. In addition, a knowledge gap in relations of COVID-19 with the previously known fatal Coronaviruses (CoVs) epidemics, SARS and MERS CoVs, was covered by investigation of sequence statistics and phylogenetics.
DOI: 10.1016/j.lfs.2020.117627
PubMed: 32251634
Affiliations:
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Electronic address: mkandeel@kfu.edu.sa.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Department of Biomedical Sciences, College of Veterinary Medicine, King Faisal University, Al-hofuf, 31982, Al-ahsa, Saudi Arabia; Department of Pharmacology, Faculty of Veterinary Medicine, Kafrelshikh University, Kafrelshikh 33516</wicri:regionArea><wicri:noRegion>Kafrelshikh 33516</wicri:noRegion></affiliation></author><author><name sortKey="Al Nazawi, Mohammed" sort="Al Nazawi, Mohammed" uniqKey="Al Nazawi M" first="Mohammed" last="Al-Nazawi">Mohammed Al-Nazawi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Sciences, College of Veterinary Medicine, King Faisal University, Al-hofuf, 31982, Al-ahsa, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Biomedical Sciences, College of Veterinary Medicine, King Faisal University, Al-hofuf, 31982, Al-ahsa</wicri:regionArea><wicri:noRegion>Al-ahsa</wicri:noRegion></affiliation></author></analytic><series><title level="j">Life sciences</title><idno type="eISSN">1879-0631</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In December 2019, the Coronavirus disease-2019 (COVID-19) virus has emerged in Wuhan, China. In this research, the first resolved COVID-19 crystal structure (main protease) was targeted in a virtual screening study by of FDA approved drugs dataset. In addition, a knowledge gap in relations of COVID-19 with the previously known fatal Coronaviruses (CoVs) epidemics, SARS and MERS CoVs, was covered by investigation of sequence statistics and phylogenetics.</div></front></TEI><affiliations><list><country><li>Arabie saoudite</li><li>Égypte</li></country></list><tree><country name="Égypte"><noRegion><name sortKey="Kandeel, Mahmoud" sort="Kandeel, Mahmoud" uniqKey="Kandeel M" first="Mahmoud" last="Kandeel">Mahmoud Kandeel</name></noRegion></country><country name="Arabie saoudite"><noRegion><name sortKey="Al Nazawi, Mohammed" sort="Al Nazawi, Mohammed" uniqKey="Al Nazawi M" first="Mohammed" last="Al-Nazawi">Mohammed Al-Nazawi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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